Autophagia

Autophagia occurs when one is compelled to inflict pain upon oneself by biting and/or devouring portions of one’s body. It is sometimes seen with schizophrenia, psychosis and Lesch–Nyhan syndrome. Similar behavior has been observed in laboratory rats in experiments looking at spinal cord and peripheral nerve injuries.

 

Cluster Number:
Wiki Number: W018
Diagnosis: Autophagia – self-eating
US Patients:
World Patients:
Sex Ratio:
Age Onset:
Brain Area:
Symptoms: self-mutilation
Progression: inflicting pain one onesself-followed by relief
Causes: schizophrenia, psychosis, or Leach-Nyhan syndrome (Not covered in Wikipedia)
Medications: Rats stopped with bitter-tasting metronidazole
Therapies:

4 CURRENT ARTICLES
FROM PUBMED

The world-wide medical research
reports chosen for each diagnosis 

Clicking each title opens the
PubMed article’s summary-abstract.

  • Role of endocrinological factors and metabolic processes in regulating life-span
    by Tamás Halmos on August 15, 2021

    Összefoglaló. Az emberek a lehető leghosszabb ideig akarnak élni, jó egészségben. Ha kiküszöbölnénk a kedvezőtlen külső körülményeket, a várható élettartam meghaladhatná a 100 évet. A 20. és 21. században a jóléti társadalmakban a várható élettartam jelentősen megnőtt, így Magyarországon is. Az áttekintett irodalom alapján megvizsgáltuk, hogy a genetika és az öröklődés mellett milyen endokrinológiai és metabolikus tényezők játszanak szerepet az élet meghosszabbításában. Megvizsgáltunk minden...

  • Contribution of "Omic" Studies to the Understanding of Cadasil. A Systematic Review
    by Elena Muiño on July 24, 2021

    CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is a small vessel disease caused by mutations in NOTCH3 that lead to an odd number of cysteines in the epidermal growth factor (EGF)-like repeat domain, causing protein misfolding and aggregation. The main symptoms are migraines, psychiatric disorders, recurrent strokes, and dementia. Omic technologies allow the massive study of different molecules for understanding diseases in a non-biased...

  • A Model of Experimental Steatosis In Vitro: Hepatocyte Cell Culture in Lipid Overload-Conditioned Medium
    by Adriana Campos-Espinosa on June 7, 2021

    Metabolic dysfunction-associated fatty liver disease (MAFLD), previously known as non-alcoholic fatty liver disease (NAFLD), is the most prevalent liver disease worldwide due to its relationship with obesity, diabetes type 2, and dyslipidemia. Hepatic steatosis, the accumulation of lipid droplets in the liver parenchyma, is a key feature of the disease preceding the inflammation observed in steatohepatitis, fibrosis, and end-stage liver disease. Lipid accumulation in hepatocytes might interfere...

  • New aspects of the development of liver diseases – with special regard to the role of autophagy and microRNA
    by Klára Werling on August 22, 2020

    Autophagy plays an important role in the homeostasis of the cells and it may be upregulated in response to several types of stresses. Deregulation of autophagy is a key mechanism in the pathogenesis and progression of several liver diseases. Deficient autophagy can contribute to liver steatosis, to endoplasmic reticulum stress and to the progression of non-alcoholic fatty liver disease. Chronic alcohol consumption inhibits autophagy. The accumulated mutant protein in the endoplasmic reticulum...